Human BMP6 Protein, His Tag

11788

Size：100 μg Price：$ 689 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11788

Product Name: Human BMP6 Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: VGR;VGR1

Target: BMP6

UNIPROT ID: P22004

Description: Recombinant human BMP6 protein with C-terminal 6xHis tag

Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016]

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 55.6 kDa after removal of the signal peptide. The apparent molecular mass of BMP6-His is approximately 40-70 kDa due to glycosylation.

Molecular Characterization: BMP6(Cys21-His513) 6×His tag

Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human BMP6 Protein, His Tag on SDS-PAGE under reducing condition.

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Human BMP6 Protein, His Tag

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