Human NLRP3 Protein, Flag Tag

11822

Size：100 μg Price：$ 659 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11822

Product Name: Human NLRP3 Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: AGTAVPRL;AII;AVP;C1orf7;CIAS1;CLR1.1;DFNA34;FCAS;FCAS1;FCU;KEFH;MWS;NALP3;PYPAF1

Target: NLRP3

UNIPROT ID: Q96P20

Description: Recombinant Human NLRP3 with C-terminal Flag tag

Background: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data, however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 121.8 kDa after removal of the signal peptide.

Molecular Characterization: NLRP3(Lys2-Trp1036) Flag

Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human NLRP3 Protein, FLAG Tag on SDS-PAGE under reducing condition.

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Human NLRP3 Protein, Flag Tag

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