Human LAIR1 Protein, hFc Tag

11909

Size：100 μg Price：$ 389 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11909

Product Name: Human LAIR1 Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: CD305;LAIR-1

Target: LAIR1

UNIPROT ID: Q6GTX8

Description: Recombinant Human LAIR1 Protein with C-terminal human Fc tag

Background: The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 41.6 kDa after removal of the signal peptide. The apparent molecular mass of LAIR1-hFc is approximately 35-70 kDa due to glycosylation.

Molecular Characterization: LAIR1(Gln22-His163) hFc(Glu99-Ala330)

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1.Human LAIR1 Protein, hFc Tag on SDS-PAGE under reducing condition.

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Human LAIR1 Protein, hFc Tag

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