Human PLAT Protein, His Tag

11972

Size：100 μg Price：$ 389 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11972

Product Name: Human PLAT Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: T-PA;TPA

Target: PLAT

UNIPROT ID: P00750

Description: Recombinant Human PLAT Protein with C-terminal 6xHis tag

Background: This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 59.9 kDa after removal of the signal peptide. The apparent molecular mass of PLAT-His is approximately 55-70 kDa due to glycosylation.

Molecular Characterization: PLAT(Ser36-Pro562) 6×His tag

Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1.Human PLAT Protein, His Tag on SDS-PAGE under reducing condition.

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Human PLAT Protein, His Tag

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