Mouse TREM2 Protein, hFc Tag

12202

Size：100 μg Price：$ 389 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 12202

Product Name: Mouse TREM2 Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: TREM-2;Trem2a;Trem2b;Trem2c

Target: TREM2

UNIPROT ID: Q99NH8

Description: Recombinant mouse TREM2 protein with C-terminal human Fc tag

Background: The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 42.9 kDa after removal of the signal peptide.

Molecular Characterization: Mouse TREM2(Leu19-Ser171) hFc(Glu99-Ala330)

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Mouse TREM2 Protein, hFc Tag on SDS-PAGE under reducing condition.

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Mouse TREM2 Protein, hFc Tag

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