Human CCR4 full length protein

12229

Size：100 μg Price：$ 1600 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 12229

Product Name: Human CCR4 Full Length Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: CC-CKR-4; CD194; ChemR13; CKR4; CMKBR4

Target: CCR4

UNIPROT ID: P51679

Description: Human CCR4 full length protein membrane nanoparticles (MNPs)

Background: The protein belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

Species/Host: HEK293

Molecular Weight: The human full length CCR4 Protein has a MW of 41.4 kDa

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure1. Elisa plates were pre-coated with 0.5 µg/per well purified human CCR4 full length membrane nanoparticles. Serial diluted anti-CCR4 monoclonal antibody (28089) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-CCR4 monoclonal antibody binding with CCR4 full length membrane nanoparticles is 308.3ng/ml.

Figure2. FACS analysis of CCR4 MNPs A. Negative Control 1: CCR4 full length membrane nanoparticles samples were stained only with Goat anti-human lgG 488 secondary antibody. B. Negative Control 2: Control membrane nanoparticles samples were stained with anti-CCR4 antibody (28089) at 2µg/ml, followed by Goat anti-human IgG 488 secondary antibody. C. Negative Control 3: CCR4 full length membrane nanoparticles samples were stained with anti-CCR8 antibody (an irrelevant antibody) at 2µg/ml, followed by Goat anti-human IgG 488 secondary antibody. D. CCR4 full length membrane nanoparticles samples were stained with anti-CCR4 antibody (28089) at 2µg/ml, followed by Goat anti-human IgG 488 secondary antibody.

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