Mouse SIRPa Protein, His Tag

12174

Size：100 μg Price：$ 550 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 12174

Product Name: Mouse SIRPa Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: SHP substrate 1;SHPS-1;Bit;MyD-1 antigen;mSIRP-alpha1;p84;CD172a

Target: SIRPa

UNIPROT ID: P97797

Description: Recombinant mouse SIRPa protein with C-terminal 6xHis tag

Background: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity).[UniProtKB/Swiss-Prot Function]

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 38.7kDa after removal of the signal peptide. The apparent molecular mass of mSIRPa-His is approximately 55-70 kDa due to glycosylation.

Molecular Characterization: Mouse SIRPa(Lys32-Asn373) 6×His tag

Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Mouse SIRPA Protein, His Tag on SDS-PAGE under reducing condition.

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Mouse SIRPa Protein, His Tag

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